Hi,
More information may be required to find the cause of this.
i) Could you provide the 400 error message and time-outs messages here. Put some log information here.
i) Do you find this issue for certain specific pages, or randomly across various pages.
ii)Do you have multiple sites hosted. And is this issue occuring across all wesites.
iii)Do we have a Network Load balancing in place, or is it a single machine.
iii) If it is only one web application facing this issue, and some specific pages, then what are we performing in those pages.
Once we have these, we may get some idea as to which direction we need to move.