ChristianHowell:With this application, if the Local Path in the Home Directory tab is a path: "D:\Folder\App", our redirect doesn't work. If the Local Path is a designator: "\App", our redirect does work. When we create the site and point to the folder, it doesn't add the designator.
What do you mean by "redirect"? How are you doing that exactly? FWIW the local path text box expects a fully qualified local drive path.
ChristianHowell:In order to change the VS publish location, I need the VS Developers group on the server. That usually means installing VS. I can't do that.
Not sure what you mean by that. You can always manually create groups.
ChristianHowell:Let me ask, for your sites on the D: drive, do you see an editable path in the Local Path field or is the field disabled with the site name?
Yes, it is all editable. Are you accessing with an account that has local admin rights?
Just re-reading your OP - what URL do you want to go to for this application?